Thermodynamic Analysis oh Chiral Separations in Normal Phase HPLC
The enantiloselectivity of mandelic acid and various optically active derivatives on a chiral stationary phase in normal phase HPLC was previously investigated. The study revealed that chiral centers with certain functional groups require bridging with methyl or ethyl groups for separation to occur. This observation is being investigated through thermodynamic analysis of two series of analytes in the same mobile phase with a view towards determining the enthalpic and entropic contributions to adsorption.
Chu, Cindy, "Thermodynamic Analysis oh Chiral Separations in Normal Phase HPLC" (2005). Honors Independent Research Papers. 21.