Histochemisty of Rat Aorta Suggests Activation of PDE4D in Balloon Angioplasty


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Balloon angioplasty (BAL) is a clinical procedure used to open and unclog arteries. Our research used male rats as models to determine whether BAL in thoracic aorta influenced an enzyme associated with arterial remodeling. One such enzyme, PDE4D, is thought to be up regulated when healing and vascular remodeling occur. Samples of aortic rings were harvested at 24 hours, 7 days, and 14 days. After rings were fixed and sectioned using standard histology, tissue slices were probed with the antibody to the enzyme phosphodiesterase type 4D (PDE4D). Results indicate that PDE4D levels increased in what appeared to be the tunica intima and media, suggesting that these smooth muscle cells were responding to blood vessel injury and healing.

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