Coordination of metronidazole to Cu(II): Structural characterization of a mononuclear square-planar compound Joshua H.

Authors

Joshua H. Palmer, Columbia University
Ja-Shin Wu, Pace University
Rita K. Upmacis, Pace University

Comments

Originally published in the Journal of Molecular Structure 1091 (2015) 177–182

dx.doi.org/10.1016/j.molstruc.2015.02.057

Document Type

Article

Abstract

The reaction between metronidazole [1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole, MET] and CuCl₂•2H₂O in methanol solution has allowed isolation of blue crystals of composition Cu(MET)₂Cl₂•MeOH. These crystals have been shown by X-ray diffraction to consist of mononuclear square-planar trans-Cu(MET)₂Cl₂ molecules in which the metronidazole ligands are trans to each other, as are the Cl ligands. The structure of this compound is very different from other compounds that have been obtained from the reaction between CuCl₂•2H₂O and metronidazole, namely [Cu(MET)₂(μ-Cl)Cl]2 and [Cu(MET)₂(μ-Cl)(OH₂)]₂[Cl]₂, which are dimers featuring bridging chloride ligands.

Recommended Citation

Palmer, Joshua H.; Wu, Ja-Shin; and Upmacis, Rita K., "Coordination of metronidazole to Cu(II): Structural characterization of a mononuclear square-planar compound Joshua H." (2015). Faculty Papers and Publications. 7.
https://digitalcommons.pace.edu/dyson_fac/7